CJC-1295 No DAC | Complete Peptide Guide

CJC-1295 NO DAC (Modified GRF 1-29) is a synthetic 29-amino-acid tetrasubstituted peptide analog of endogenous Growth Hormone-Releasing Hormone (GHRH). By incorporating selective amino acid substitutions ($\text{D-Ala}^2$, $\text{Gln}^8$, $\text{Ala}^{15}$, and $\text{Leu}^{27}$), CJC-1295 NO DAC offers enhanced plasma stability against dipeptidyl peptidase-IV (DPP-IV) cleavage compared to native GHRH (1-29). Lacking the Drug Affinity Complex (DAC) maleimide moiety, CJC-1295 NO DAC exhibits rapid binding kinetics without long-term albumin conjugation, making it an ideal reference standard for short-duration secretagogue pulse signaling assays.

CJC-1295 No DAC | Peptide Information

Solubilization: Dissolves rapidly in sterile bacteriostatic water or $0.1\text{M}$ acetic acid at target concentrations of $1.0\text{ mg/mL}$ to $2.0\text{ mg/mL}$.Handling Protocol: Add solvent along the inner vial wall. Gently swirl until the solute clears. Avoid aggressive vortexing or mechanical mixing to protect peptide backbone stability.

CJC-1295 No DAC Online

Lyophilized State: Maintain desiccated at $-20^\circ\text{C}$ to $-80^\circ\text{C}$ for multi-year stability.Liquid Phase: Store hydrated aliquots at $2^\circ\text{C}$ to $8^\circ\text{C}$ for up to 21 days. For extended studies, store single-use aliquots at $-80^\circ\text{C}$ to prevent thermal degradation and eliminate repeat freeze-thaw cycles.

Understanding CJC-1295 No DAC | Peptide Overview

GHRP-2 (Pralmorelin) is a synthetic hexapeptide classified as a Growth Hormone Secretagogue (GHS) and selective agonist of the Growth Hormone Secretagogue Receptor (GHSR-1a / ghrelin receptor). Composed of a compact 6-amino-acid sequence ($\text{D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH}_2$), GHRP-2 demonstrates strong receptor affinity and metabolic stability in cell culture models. In comparative multi-peptide assays, GHRP-2 is frequently evaluated alongside GHRH analogs like CJC-1295 NO DAC to analyze dual-pathway activation dynamics across pituitary somatotroph populations.

Reconstitution & Buffer Compatibility

Solubilization: Highly water-soluble. Reconstitute using sterile bacteriostatic water, sterile water, or phosphate-buffered saline (PBS, pH 7.4) to a stock density of $1.0\text{ mg/mL}$ to $5.0\text{ mg/mL}$.Handling Protocol: Hydrates easily upon contact with aqueous media; mild agitation ensures uniform concentration across working aliquots.

Storage & Stability Directives

Lyophilized State: Store dry powder at $-20^\circ\text{C}$ to $-80^\circ\text{C}$.Liquid Phase: Reconstituted GHRP-2 exhibits high stability; keep refrigeration temperatures at $2^\circ\text{C}$ to $8^\circ\text{C}$ for short-term evaluation, and shield from direct UV light exposure.

Every batch of CJC-1295 NO DAC and GHRP-2 supplied by AU Peptides Store undergoes strict analytical verification prior to laboratory release:High-Performance Liquid Chromatography (HPLC): Confirms $\ge 99.0\%$ analytical purity and verifies zero residual synthetic side-products or truncated fragments.